Found 443 hits with Last Name = 'zhang' and Initial = 'hq' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Nitric oxide synthase, inducible
(Mus musculus (mouse)) | BDBM50061231
(2-Amino-5-(N'-propyl-guanidino)-pentanoic acid | C...)Show InChI InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouse |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50061231
(2-Amino-5-(N'-propyl-guanidino)-pentanoic acid | C...)Show InChI InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against neuronal nitric oxide synthase(nNOS) |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50061230
(1-Acetyl-4-(N'-allyl-guanidino)-butyl-ammonium)Show InChI InChI=1S/C10H20N4O/c1-3-6-13-10(12)14-7-4-5-9(11)8(2)15/h3,9H,1,4-7,11H2,2H3,(H3,12,13,14)/p+1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against neuronal nitric oxide synthase(nNOS) |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50061232
(2-Amino-5-(N'-prop-2-ynyl-guanidino)-pentanoic aci...)Show InChI InChI=1S/C9H16N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h1,7H,3-6,10H2,(H,14,15)(H3,11,12,13) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against neuronal nitric oxide synthase(nNOS) |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Mus musculus (mouse)) | BDBM50061232
(2-Amino-5-(N'-prop-2-ynyl-guanidino)-pentanoic aci...)Show InChI InChI=1S/C9H16N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h1,7H,3-6,10H2,(H,14,15)(H3,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouse |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Bos taurus (bovine)) | BDBM50061232
(2-Amino-5-(N'-prop-2-ynyl-guanidino)-pentanoic aci...)Show InChI InChI=1S/C9H16N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h1,7H,3-6,10H2,(H,14,15)(H3,11,12,13) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against Endothelial nitric oxide synthase |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Mus musculus (mouse)) | BDBM50061230
(1-Acetyl-4-(N'-allyl-guanidino)-butyl-ammonium)Show InChI InChI=1S/C10H20N4O/c1-3-6-13-10(12)14-7-4-5-9(11)8(2)15/h3,9H,1,4-7,11H2,2H3,(H3,12,13,14)/p+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouse |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Bos taurus (bovine)) | BDBM50061230
(1-Acetyl-4-(N'-allyl-guanidino)-butyl-ammonium)Show InChI InChI=1S/C10H20N4O/c1-3-6-13-10(12)14-7-4-5-9(11)8(2)15/h3,9H,1,4-7,11H2,2H3,(H3,12,13,14)/p+1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against Endothelial nitric oxide synthase |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Bos taurus (bovine)) | BDBM50030279
(2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | C...)Show InChI InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against Endothelial nitric oxide synthase |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Mus musculus (mouse)) | BDBM50061233
(2-Amino-5-(N'-ethyl-guanidino)-pentanoic acid | CH...)Show InChI InChI=1S/C8H18N4O2/c1-2-11-8(10)12-5-3-4-6(9)7(13)14/h6H,2-5,9H2,1H3,(H,13,14)(H3,10,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouse |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Bos taurus (bovine)) | BDBM50061231
(2-Amino-5-(N'-propyl-guanidino)-pentanoic acid | C...)Show InChI InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against Endothelial nitric oxide synthase |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, endothelial
(Bos taurus (bovine)) | BDBM50061233
(2-Amino-5-(N'-ethyl-guanidino)-pentanoic acid | CH...)Show InChI InChI=1S/C8H18N4O2/c1-2-11-8(10)12-5-3-4-6(9)7(13)14/h6H,2-5,9H2,1H3,(H,13,14)(H3,10,11,12) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against Endothelial nitric oxide synthase |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50030279
(2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | C...)Show InChI InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against neuronal nitric oxide synthase(nNOS) |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, inducible
(Mus musculus (mouse)) | BDBM50030279
(2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | C...)Show InChI InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouse |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Nitric oxide synthase, brain
(Rattus norvegicus (rat)) | BDBM50061233
(2-Amino-5-(N'-ethyl-guanidino)-pentanoic acid | CH...)Show InChI InChI=1S/C8H18N4O2/c1-2-11-8(10)12-5-3-4-6(9)7(13)14/h6H,2-5,9H2,1H3,(H,13,14)(H3,10,11,12) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against neuronal nitric oxide synthase(nNOS) |
J Med Chem 40: 3869-70 (1998)
Article DOI: 10.1021/jm970550g BindingDB Entry DOI: 10.7270/Q2C829ZT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50210747
(CHEMBL3968039)Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C32H38ClN7O3/c1-21-6-7-23(16-22(21)2)37-32(41)38-27-9-8-24(17-26(27)33)36-31-25-18-29(42-4)30(19-28(25)34-20-35-31)43-15-5-10-40-13-11-39(3)12-14-40/h6-9,16-20H,5,10-15H2,1-4H3,(H,34,35,36)(H2,37,38,41) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ... |
Eur J Med Chem 125: 245-254 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.039 BindingDB Entry DOI: 10.7270/Q2QJ7K9C |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50210697
(CHEMBL3962233)Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C30H33Cl2N7O3/c1-38-11-13-39(14-12-38)10-3-15-42-28-18-26-23(17-27(28)41-2)29(34-19-33-26)35-22-8-9-25(24(32)16-22)37-30(40)36-21-6-4-20(31)5-7-21/h4-9,16-19H,3,10-15H2,1-2H3,(H,33,34,35)(H2,36,37,40) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ... |
Eur J Med Chem 125: 245-254 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.039 BindingDB Entry DOI: 10.7270/Q2QJ7K9C |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50210272
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Flt1 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210309
(4-methyl-1-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)C(=O)C1 Show InChI InChI=1S/C29H26N4O2S/c1-32-11-12-33(27(34)18-32)17-20-9-10-25-21(14-20)16-26-28(30-31-29(25)26)22-15-24(36-19-22)8-5-13-35-23-6-3-2-4-7-23/h2-4,6-7,9-10,14-15,19H,11-13,16-18H2,1H3,(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50210272
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Flt4 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Flt3 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210300
(CHEMBL225311 | N-(3-(4-(6-((4-methylpiperazin-1-yl...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCNC(=O)c3ccccc3)c2)CC1 Show InChI InChI=1S/C30H29N5OS/c1-34-12-14-35(15-13-34)19-21-9-10-26-23(16-21)18-27-28(32-33-29(26)27)24-17-25(37-20-24)8-5-11-31-30(36)22-6-3-2-4-7-22/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,31,36)(H,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Flt1 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Flt4 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210300
(CHEMBL225311 | N-(3-(4-(6-((4-methylpiperazin-1-yl...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCNC(=O)c3ccccc3)c2)CC1 Show InChI InChI=1S/C30H29N5OS/c1-34-12-14-35(15-13-34)19-21-9-10-26-23(16-21)18-27-28(32-33-29(26)27)24-17-25(37-20-24)8-5-11-31-30(36)22-6-3-2-4-7-22/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,31,36)(H,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by ELISA |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210299
(6-(2-(4-methylpiperazin-1-yl)ethyl)-3-(5-(3-phenox...)Show SMILES CN1CCN(CCc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C30H30N4OS/c1-33-13-15-34(16-14-33)12-11-22-9-10-27-23(18-22)20-28-29(31-32-30(27)28)24-19-26(36-21-24)8-5-17-35-25-6-3-2-4-7-25/h2-4,6-7,9-10,18-19,21H,11-17,20H2,1H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210272
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210309
(4-methyl-1-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)C(=O)C1 Show InChI InChI=1S/C29H26N4O2S/c1-32-11-12-33(27(34)18-32)17-20-9-10-25-21(14-20)16-26-28(30-31-29(25)26)22-15-24(36-19-22)8-5-13-35-23-6-3-2-4-7-23/h2-4,6-7,9-10,14-15,19H,11-13,16-18H2,1H3,(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR kinase by HTRF assay |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210269
(4-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihyd...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCCO)c2)CC1 Show InChI InChI=1S/C24H26N4OS/c1-27-7-9-28(10-8-27)15-17-5-6-21-18(12-17)14-22-23(25-26-24(21)22)19-13-20(30-16-19)4-2-3-11-29/h5-6,12-13,16,29H,3,7-11,14-15H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50210272
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CSF1R |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210277
(3-(5-(3-methoxyprop-1-ynyl)thiophen-3-yl)-6-((4-me...)Show SMILES COCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21 Show InChI InChI=1S/C24H26N4OS/c1-27-7-9-28(10-8-27)15-17-5-6-21-18(12-17)14-22-23(25-26-24(21)22)19-13-20(30-16-19)4-3-11-29-2/h5-6,12-13,16H,7-11,14-15H2,1-2H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50210272
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Flt3 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CSF1R |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210293
(4-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3-yl)-1,4-...)Show SMILES NC(=O)N1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H27N5O2S/c30-29(35)34-12-10-33(11-13-34)18-20-8-9-25-21(15-20)17-26-27(31-32-28(25)26)22-16-24(37-19-22)7-4-14-36-23-5-2-1-3-6-23/h1-3,5-6,8-9,15-16,19H,10-14,17-18H2,(H2,30,35)(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR kinase by HTRF assay |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ... |
Eur J Med Chem 109: 371-9 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.032 BindingDB Entry DOI: 10.7270/Q2M32XKS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210296
(3-(5-(3-(2-methoxyethoxy)prop-1-ynyl)thiophen-3-yl...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc2-c3ccc(CN4CCN(C)CC4)cc3C(=O)c12 Show InChI InChI=1S/C26H28N4O3S/c1-29-7-9-30(10-8-29)16-18-5-6-21-22(14-18)26(31)23-24(27-28-25(21)23)19-15-20(34-17-19)4-3-11-33-13-12-32-2/h5-6,14-15,17H,7-13,16H2,1-2H3,(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210306
(6-(4-methylpiperazin-1-yl)-3-(5-(3-phenoxyprop-1-y...)Show SMILES CN1CCN(CC1)c1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1 Show InChI InChI=1S/C28H26N4OS/c1-31-11-13-32(14-12-31)22-9-10-25-20(16-22)18-26-27(29-30-28(25)26)21-17-24(34-19-21)8-5-15-33-23-6-3-2-4-7-23/h2-4,6-7,9-10,16-17,19H,11-15,18H2,1H3,(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210284
(CHEMBL374690 | N,N-dimethyl-2-(3-(5-(3-phenoxyprop...)Show SMILES CN(C)C(=O)COc1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3S/c1-30(2)25(31)16-33-21-10-11-23-18(13-21)15-24-26(28-29-27(23)24)19-14-22(34-17-19)9-6-12-32-20-7-4-3-5-8-20/h3-5,7-8,10-11,13-14,17H,12,15-16H2,1-2H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210316
(3-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3-yl)-1,4-...)Show SMILES C(Oc1ccccc1)C#Cc1cc(cs1)-c1[nH]nc-2c1Cc1cc(CN3CCSC3)ccc-21 Show InChI InChI=1S/C27H23N3OS2/c1-2-5-22(6-3-1)31-11-4-7-23-14-21(17-33-23)26-25-15-20-13-19(16-30-10-12-32-18-30)8-9-24(20)27(25)29-28-26/h1-3,5-6,8-9,13-14,17H,10-12,15-16,18H2,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210305
(1-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-di...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCNC(=O)Nc3ccccc3)c2)CC1 Show InChI InChI=1S/C30H30N6OS/c1-35-12-14-36(15-13-35)19-21-9-10-26-22(16-21)18-27-28(33-34-29(26)27)23-17-25(38-20-23)8-5-11-31-30(37)32-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,33,34)(H2,31,32,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR kinase by HTRF assay |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50188749
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR at 1 mM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 4266-71 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.066 BindingDB Entry DOI: 10.7270/Q2NP242Q |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210314
(6-((1-methylpiperidin-4-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCC(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C30H29N3OS/c1-33-13-11-21(12-14-33)16-22-9-10-27-23(17-22)19-28-29(31-32-30(27)28)24-18-26(35-20-24)8-5-15-34-25-6-3-2-4-7-25/h2-4,6-7,9-10,17-18,20-21H,11-16,19H2,1H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR kinase by HTRF assay |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM21
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ... |
Eur J Med Chem 125: 245-254 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.039 BindingDB Entry DOI: 10.7270/Q2QJ7K9C |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210306
(6-(4-methylpiperazin-1-yl)-3-(5-(3-phenoxyprop-1-y...)Show SMILES CN1CCN(CC1)c1ccc-2c(Cc3c-2n[nH]c3-c2csc(c2)C#CCOc2ccccc2)c1 Show InChI InChI=1S/C28H26N4OS/c1-31-11-13-32(14-12-31)22-9-10-25-20(16-22)18-26-27(29-30-28(25)26)21-17-24(34-19-21)8-5-15-33-23-6-3-2-4-7-23/h2-4,6-7,9-10,16-17,19H,11-15,18H2,1H3,(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210285
(1-methyl-4-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1=O Show InChI InChI=1S/C29H26N4O2S/c1-32-11-12-33(18-27(32)34)17-20-9-10-25-21(14-20)16-26-28(30-31-29(25)26)22-15-24(36-19-22)8-5-13-35-23-6-3-2-4-7-23/h2-4,6-7,9-10,14-15,19H,11-13,16-18H2,1H3,(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR kinase by HTRF assay |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50188753
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR at 1 mM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 4266-71 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.066 BindingDB Entry DOI: 10.7270/Q2NP242Q |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of c-Kit |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50210296
(3-(5-(3-(2-methoxyethoxy)prop-1-ynyl)thiophen-3-yl...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc2-c3ccc(CN4CCN(C)CC4)cc3C(=O)c12 Show InChI InChI=1S/C26H28N4O3S/c1-29-7-9-30(10-8-29)16-18-5-6-21-22(14-18)26(31)23-24(27-28-25(21)23)19-15-20(34-17-19)4-3-11-33-13-12-32-2/h5-6,14-15,17H,7-13,16H2,1-2H3,(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50188731
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)s3)c2)CC1 Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-2-8-23-19(14-18)15-24-26(23)35-36-27(24)25-9-7-22(40-25)16-33-28(39)34-21-5-3-20(4-6-21)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of cKit at 1 mM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 4266-71 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.066 BindingDB Entry DOI: 10.7270/Q2NP242Q |
More data for this Ligand-Target Pair | |