| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 3 |
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| Ligand | BDBM50189014 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_395994 (CHEMBL910339) |
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| Ki | 7±n/a nM |
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| Citation |  Tian, X; Mishra, RK; Switzer, AG; Hu, XE; Kim, N; Mazur, AW; Ebetino, FH; Wos, JA; Crossdoersen, D; Pinney, BB; Farmer, JA; Sheldon, RJ Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett16:4668-73 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 3 |
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| Name: | Melanocortin receptor 3 |
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| Synonyms: | MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36044.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41968 |
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| Residue: | 323 |
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| Sequence: | MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
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| BDBM50189014 |
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| n/a |
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| Name | BDBM50189014 |
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| Synonyms: | (S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)propanoyl)-3-(3-guanidinopropyl)-2-oxopiperazin-1-yl)-N-methyl-3-(naphthalen-2-yl)propanamide | CHEMBL384176 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40FN7O4 |
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| Mol. Mass. | 617.7136 |
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| SMILES | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O |
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| Structure | 
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