| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 2 |
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| Ligand | BDBM50212928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_447408 (CHEMBL896432) |
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| IC50 | 61000±n/a nM |
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| Citation |  Gao, YD; Feng, D; Sheridan, RP; Scapin, G; Patel, SB; Wu, JK; Zhang, X; Sinha-Roy, R; Thornberry, NA; Weber, AE; Biftu, T Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors. Bioorg Med Chem Lett17:3877-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 2 |
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| Name: | Dipeptidyl peptidase 2 |
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| Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
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| Type: | Protein |
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| Mol. Mass.: | 54339.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHL4 |
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| Residue: | 492 |
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| Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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| BDBM50212928 |
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| n/a |
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| Name | BDBM50212928 |
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| Synonyms: | (1S,2R,5S)-5-(2-cyclopropyl-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine | CHEMBL233563 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F3N4 |
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| Mol. Mass. | 388.4293 |
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| SMILES | N[C@H]1C[C@H](CC[C@@H]1c1cc(F)c(F)cc1F)N1Cc2cnc(nc2C1)C1CC1 |
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| Structure | 
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