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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50220720 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449356 (CHEMBL899623) | ||
| IC50 | 85±n/a nM | ||
| Citation |  Kawai, M; Nakamura, H; Sakurada, I; Shimokawa, H; Tanaka, H; Matsumizu, M; Ando, K; Hattori, K; Ohta, A; Nukui, S; Omura, A; Kawamura, M Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. Bioorg Med Chem Lett17:5533-6 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
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| BDBM50220720 | |||
| n/a | |||
| Name | BDBM50220720 | ||
| Synonyms: | CHEMBL237752 | N-((1s,4s)-4-hydroxy-4-(2-oxo-2,3-dihydrooxazolo[4,5-b]pyridin-6-yl)cyclohexyl)-3-phenylpropanamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23N3O4 | ||
| Mol. Mass. | 381.425 | ||
| SMILES | O[C@@]1(CC[C@@H](CC1)NC(=O)CCc1ccccc1)c1c[nH]c2nc(=O)oc2c1 |wD:1.0,4.7,(16.47,-54.83,;16.48,-53.3,;16.48,-51.76,;17.81,-50.98,;19.14,-51.76,;19.14,-53.3,;17.81,-54.07,;20.48,-51,;21.81,-51.77,;21.81,-53.31,;23.16,-51.01,;24.48,-51.79,;25.81,-51.02,;27.13,-51.8,;28.47,-51.05,;28.49,-49.51,;27.17,-48.73,;25.83,-49.48,;15.14,-54.08,;15.16,-55.61,;13.83,-56.39,;12.47,-55.63,;11.01,-56.1,;10.1,-54.85,;8.55,-54.85,;11.01,-53.6,;12.48,-54.08,;13.81,-53.31,)| | ||
| Structure | 
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