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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50220731 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449356 (CHEMBL899623) | ||
| IC50 | >1000±n/a nM | ||
| Citation |  Kawai, M; Nakamura, H; Sakurada, I; Shimokawa, H; Tanaka, H; Matsumizu, M; Ando, K; Hattori, K; Ohta, A; Nukui, S; Omura, A; Kawamura, M Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. Bioorg Med Chem Lett17:5533-6 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
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| BDBM50220731 | |||
| n/a | |||
| Name | BDBM50220731 | ||
| Synonyms: | CHEMBL393609 | N-((1r,4r)-4-(4-hydroxyphenyl)cyclohexyl)-3-(1-methyl-1H-benzo[d]imidazol-2-yl)propanamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H27N3O2 | ||
| Mol. Mass. | 377.4794 | ||
| SMILES | Cn1c(CCC(=O)N[C@H]2CC[C@@H](CC2)c2ccc(O)cc2)nc2ccccc12 |wU:11.14,wD:8.7,(27.83,-9.24,;27.07,-7.91,;25.61,-7.43,;24.27,-8.19,;22.94,-7.41,;21.6,-8.17,;21.6,-9.72,;20.26,-7.4,;18.93,-8.17,;17.58,-7.38,;16.25,-8.17,;16.25,-9.71,;17.58,-10.48,;18.93,-9.71,;14.92,-10.49,;13.58,-9.71,;12.24,-10.49,;12.24,-12.04,;10.91,-12.81,;13.59,-12.8,;14.93,-12.03,;25.61,-5.89,;27.08,-5.42,;27.84,-3.92,;29.37,-3.9,;30.15,-5.23,;29.39,-6.56,;27.85,-6.57,)| | ||
| Structure | 
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