| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50227722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_459993 (CHEMBL944036) |
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| IC50 | 3230±n/a nM |
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| Citation |  Whitlock, GA; Dack, KN; Dickinson, RP; Lewis, ML A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett17:6750-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50227722 |
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| n/a |
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| Name | BDBM50227722 |
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| Synonyms: | CHEMBL398641 | N-hydroxy-2-{4-[3'-(2-hydroxy-ethoxy)-2-methyl-biphenyl-4-yl]-piperidine-1-sulfonyl}-2-methyl-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N2O6S |
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| Mol. Mass. | 476.586 |
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| SMILES | Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO |
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| Structure | 
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