| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
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| Ligand | BDBM50263675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_536095 (CHEMBL995041) |
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| EC50 | >30000±n/a nM |
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| Citation |  Jolidon, S; Alberati, D; Dowle, A; Fischer, H; Hainzl, D; Narquizian, R; Norcross, R; Pinard, E Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1. Bioorg Med Chem Lett18:5533-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 2 |
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| Name: | Sodium- and chloride-dependent glycine transporter 2 |
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| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 87438.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
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| Residue: | 797 |
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| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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| BDBM50263675 |
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| n/a |
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| Name | BDBM50263675 |
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| Synonyms: | 4-fluoro-N-(2-oxo-2-(phenyl(o-tolyl)methylamino)ethyl)benzamide | CHEMBL476775 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21FN2O2 |
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| Mol. Mass. | 376.4234 |
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| SMILES | Cc1ccccc1C(NC(=O)CNC(=O)c1ccc(F)cc1)c1ccccc1 |
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| Structure | 
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