| Reaction Details |
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 | Report a problem with these data |
| Target | Small conductance calcium-activated potassium channel protein 2 |
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| Ligand | BDBM50275960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497521 (CHEMBL995896) |
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| IC50 | 530±n/a nM |
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| Citation |  Gentles, RG; Hu, S; Huang, Y; Grant-Young, K; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers. Bioorg Med Chem Lett18:5694-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Small conductance calcium-activated potassium channel protein 2 |
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| Name: | Small conductance calcium-activated potassium channel protein 2 |
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| Synonyms: | KCNN2 | KCNN2_HUMAN | SK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63788.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_480083 |
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| Residue: | 579 |
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| Sequence: | MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVS
SSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYK
LGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTII
LLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTAR
LAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF
VMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIG
YGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK
NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLV
DLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFI
EAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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| BDBM50275960 |
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| n/a |
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| Name | BDBM50275960 |
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| Synonyms: | 5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine | CHEMBL472452 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H9ClN4S |
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| Mol. Mass. | 264.734 |
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| SMILES | Clc1cc(NCc2cccs2)n2nccc2n1 |
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| Structure | 
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