| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50282413 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35440 (CHEMBL643800) |
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| IC50 | >10000±n/a nM |
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| Citation |  Naylor, EM; Chakravarty, PK; Costello, CA; Chang, RS; Chen, TB; Faust, KA; Lotti, VJ; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Wong, PC; Carini, DJ; Wexler, RR; Patchett, AA; Greenlee, WJ Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements Bioorg Med Chem Lett4:69-74 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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| BDBM50282413 |
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| n/a |
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| Name | BDBM50282413 |
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| Synonyms: | Acyl sulfonamide derivative | CHEMBL163485 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N4O5S |
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| Mol. Mass. | 496.579 |
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| SMILES | CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)C1CC1 |
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| Structure | 
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