| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50284892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_98639 |
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| IC50 | 170±n/a nM |
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| Citation |  Lau, CK; Dufresne, C; Gareau, Y; Zamboni, R; Labelle, M; Young, RN; Metters, KM; Rochette, C; Sawyer, N; Slipetz, DM; Charette, L; Jones, T; McAuliffe, M; McFarlane, C; Ford-Hutchinson, AW Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists Bioorg Med Chem Lett5:1615-1620 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39007.58 |
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| Organism: | GUINEA PIG |
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| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
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| Residue: | 340 |
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| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
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| BDBM50284892 |
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| n/a |
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| Name | BDBM50284892 |
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| Synonyms: | (1-{(R)-1-{3-[(E)-2-(5-Chloro-4-isopropyl-thiazol-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid | CHEMBL297396 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38ClNO3S2 |
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| Mol. Mass. | 584.232 |
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| SMILES | CC(C)c1nc(\C=C\c2cccc(c2)[C@@H](CCc2ccccc2C(C)(C)O)SCC2(CC(O)=O)CC2)sc1Cl |
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| Structure | 
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