| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled receptor homolog US28 |
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| Ligand | BDBM50027209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321572 (CHEMBL881787) |
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| IC50 | 45700±n/a nM |
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| Citation |  Hulshof, JW; Casarosa, P; Menge, WM; Kuusisto, LM; van der Goot, H; Smit, MJ; de Esch, IJ; Leurs, R Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem48:6461-71 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled receptor homolog US28 |
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| Name: | G-protein coupled receptor homolog US28 |
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| Synonyms: | Human herpesvirus 5 chemokine receptor | US28 | US28_HCMVA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41070.46 |
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| Organism: | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
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| Description: | ChEMBL_322135 |
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| Residue: | 354 |
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| Sequence: | MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITW
RRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLC
FITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYL
EVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIF
WLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQ
ELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
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| BDBM50027209 |
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| n/a |
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| Name | BDBM50027209 |
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| Synonyms: | 5-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile | CHEMBL371031 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28ClF3N2O |
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| Mol. Mass. | 512.994 |
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| SMILES | OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)c(c1)C(F)(F)F |
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| Structure | 
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