| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50296095 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579418 (CHEMBL1053173) |
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| IC50 | 1.2±n/a nM |
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| Citation |  Bonjoch, J; Diaba, F; Pagès, L; Pérez, D; Soca, L; Miralpeix, M; Vilella, D; Anton, P; Puig, C Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists. Bioorg Med Chem Lett19:4299-302 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39007.58 |
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| Organism: | GUINEA PIG |
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| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
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| Residue: | 340 |
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| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
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| BDBM50296095 |
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| n/a |
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| Name | BDBM50296095 |
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| Synonyms: | 2-(2-(1H-tetrazol-5-yl)ethyl)-9-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | CHEMBL560522 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H28ClN7 |
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| Mol. Mass. | 546.065 |
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| SMILES | Clc1ccc2ccc(C=Cc3cccc(Cn4c5CN(CCc6nnn[nH]6)CCc5c5ccccc45)c3)nc2c1 |w:9.9| |
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| Structure | 
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