Reaction Details |
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Target | Sonic hedgehog protein |
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Ligand | BDBM50249522 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_598862 (CHEMBL1044694) |
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IC50 | 13±n/a nM |
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Citation | Robarge, KD; Brunton, SA; Castanedo, GM; Cui, Y; Dina, MS; Goldsmith, R; Gould, SE; Guichert, O; Gunzner, JL; Halladay, J; Jia, W; Khojasteh, C; Koehler, MF; Kotkow, K; La, H; Lalonde, RL; Lau, K; Lee, L; Marshall, D; Marsters, JC; Murray, LJ; Qian, C; Rubin, LL; Salphati, L; Stanley, MS; Stibbard, JH; Sutherlin, DP; Ubhayaker, S; Wang, S; Wong, S; Xie, M GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett19:5576-81 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sonic hedgehog protein |
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Name: | Sonic hedgehog protein |
Synonyms: | Hhg1 | SHH_MOUSE | Shh |
Type: | Protein |
Mol. Mass.: | 47784.50 |
Organism: | Mus musculus (Mouse) |
Description: | Q62226 |
Residue: | 437 |
Sequence: | MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGAS
GRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKA
HIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFL
TFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQR
VYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAH
RAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTW
LLDSETMHPLGMAVKSS
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BDBM50249522 |
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n/a |
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Name | BDBM50249522 |
Synonyms: | 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide | CHEMBL473417 | VISMODEGIB |
Type | Small organic molecule |
Emp. Form. | C19H14Cl2N2O3S |
Mol. Mass. | 421.297 |
SMILES | CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1 |
Structure |
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