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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50317587 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_632331 (CHEMBL1112959) | ||
| IC50 | 14.7±n/a nM | ||
| Citation |  Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors. Bioorg Med Chem Lett20:2765-9 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41281.22 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50317587 | |||
| n/a | |||
| Name | BDBM50317587 | ||
| Synonyms: | 6-(2,4-difluorophenyl)-1-(2-fluoro-5-(1,3,4-oxadiazol-2-yl)phenyl)-2H-quinolizin-2-one | CHEMBL1098554 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H12F3N3O2 | ||
| Mol. Mass. | 419.3555 | ||
| SMILES | Fc1ccc(c(F)c1)-c1cccc2c(-c3cc(ccc3F)-c3nnco3)c(=O)ccn12 |(12.42,-9.58,;12.42,-8.04,;11.08,-7.27,;11.09,-5.73,;12.43,-4.96,;13.76,-5.73,;15.09,-4.95,;13.76,-7.26,;12.43,-3.42,;13.76,-2.65,;13.75,-1.11,;12.42,-.35,;11.1,-1.11,;9.77,-.33,;9.77,1.21,;11.11,1.97,;11.11,3.51,;9.77,4.29,;8.43,3.51,;8.44,1.97,;7.11,1.2,;12.44,4.28,;13.91,3.83,;14.8,5.09,;13.87,6.32,;12.42,5.83,;8.44,-1.11,;7.1,-.35,;8.44,-2.65,;9.77,-3.42,;11.1,-2.65,)| | ||
| Structure | 
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