Ki Summary

Reaction Details

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Target

Nuclear receptor subfamily 1 group I member 2

Ligand

BDBM50317585

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_632337 (CHEMBL1112965)

EC50

>30000±n/a nM

Citation

Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors. Bioorg Med Chem Lett20:2765-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Nuclear receptor subfamily 1 group I member 2

Name:

Nuclear receptor subfamily 1 group I member 2

Synonyms:

Type:

Nuclear receptor

Mol. Mass.:

49774.77

Organism:

Homo sapiens (Human)

Description:

O75469

Residue:

434

Sequence:

MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS

BDBM50317585

n/a

Name

BDBM50317585

Synonyms:

1-(4-(5-amino-1,3,4-oxadiazol-2-yl)-2,6-difluorophenyl)-6-(2,4-difluorophenyl)-2H-quinolizin-2-one | CHEMBL1098551

Type

Small organic molecule

Emp. Form.

C23H12F4N4O2

Mol. Mass.

452.3606

SMILES

Nc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(24.64,-30.2,;25.55,-31.45,;27.09,-31.45,;27.57,-32.91,;26.32,-33.82,;25.07,-32.92,;26.32,-35.37,;27.65,-36.14,;27.65,-37.68,;28.99,-38.45,;26.32,-38.45,;24.99,-37.68,;23.65,-38.45,;24.98,-36.14,;26.32,-39.98,;27.64,-40.76,;28.97,-40,;30.3,-40.76,;30.3,-42.3,;28.97,-43.07,;28.97,-44.6,;27.63,-45.37,;27.63,-46.91,;28.96,-47.68,;28.96,-49.22,;30.3,-46.91,;30.3,-45.37,;31.63,-44.6,;27.64,-42.3,;26.32,-43.06,;24.99,-42.3,;24.99,-40.76,;23.65,-40,)|

Structure