Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50329297 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_675392 (CHEMBL1273472) | ||
| IC50 | 3.8±n/a nM | ||
| Citation |  Tice, CM; Zhao, W; Krosky, PM; Kruk, BA; Berbaum, J; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Howard, L; Togias, J; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, PR; Guo, J; Guo, R; Nar, H; Schuler-Metz, A; Gregg, RE; Leftheris, K; Harrison, RK; McGeehan, GM; Zhuang, L; Claremon, DA Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1. Bioorg Med Chem Lett20:6725-9 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| BDBM50329297 | |||
| n/a | |||
| Name | BDBM50329297 | ||
| Synonyms: | (R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid 5-hydroxy-adamantan-2-yl ester | CHEMBL1270604 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H32N2O5 | ||
| Mol. Mass. | 380.4785 | ||
| SMILES | CC(C)(C)OC(=O)N[C@@H]1CCN(C1)C(=O)O[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:8.7,16.16,wD:23.25,TLB:16:17:25:20.21.22,15:16:25.19.20:22,THB:18:19:22:26.17.16,18:17:25.19.20:22,16:21:25:26.18.17,(6.15,-33.79,;4.61,-33.76,;3.86,-32.41,;5.37,-32.42,;3.82,-35.08,;2.28,-35.06,;1.53,-33.71,;1.49,-36.38,;-.05,-36.35,;-.93,-35.09,;-2.41,-35.54,;-2.43,-37.09,;-.98,-37.58,;-3.78,-37.85,;-3.79,-39.39,;-5.1,-37.07,;-6.44,-37.82,;-6.45,-39.35,;-7.47,-40.63,;-8.87,-40.06,;-8.88,-38.48,;-7.84,-37.24,;-9.18,-37.72,;-9.18,-39.21,;-10.52,-38.43,;-10.37,-40.48,;-7.85,-39.7,)| | ||
| Structure | 
| ||