Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50329305 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_675393 (CHEMBL1273473) | ||
IC50 | 16.4±n/a nM | ||
Citation | Tice, CM; Zhao, W; Krosky, PM; Kruk, BA; Berbaum, J; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Howard, L; Togias, J; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, PR; Guo, J; Guo, R; Nar, H; Schuler-Metz, A; Gregg, RE; Leftheris, K; Harrison, RK; McGeehan, GM; Zhuang, L; Claremon, DA Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1. Bioorg Med Chem Lett20:6725-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50329305 | |||
n/a | |||
Name | BDBM50329305 | ||
Synonyms: | (R)-3-(4-Trifluoromethyl-pyrimidin-2-ylamino)-pyrrolidine-1-carboxylic acid 5-carbamoyl-adamantan-2-yl ester | CHEMBL1271010 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H26F3N5O3 | ||
Mol. Mass. | 453.458 | ||
SMILES | NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Nc1nccc(n1)C(F)(F)F)C(C3)C2 |r,wU:16.19,9.10,wD:3.2,TLB:6:5:31:8.7.9,6:7:4.5.30:31,THB:9:7:4:30.29.31,9:29:4:8.6.7,10:9:4.5.30:31,(-10.48,-11.09,;-9.13,-10.31,;-9.13,-8.77,;-7.79,-11.09,;-8.99,-12.37,;-7.49,-11.95,;-6.08,-12.51,;-5.07,-11.23,;-6.46,-11.58,;-5.06,-9.71,;-3.72,-8.95,;-2.39,-9.73,;-2.41,-11.27,;-1.05,-8.97,;-1.02,-7.43,;.45,-6.98,;1.33,-8.24,;.41,-9.47,;2.87,-8.26,;3.67,-6.94,;5.21,-6.97,;6,-5.65,;5.25,-4.31,;3.7,-4.28,;2.92,-5.61,;2.95,-2.94,;3.73,-1.62,;1.41,-2.92,;2.16,-1.6,;-6.45,-9.13,;-7.49,-10.36,;-7.8,-9.61,)| | ||
Structure |