Reaction Details |
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Target | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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Ligand | BDBM50338236 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_727955 (CHEMBL1686753) |
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IC50 | >100000±n/a nM |
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Citation | Takahashi, H; Shinoyama, M; Komine, T; Nagao, M; Suzuki, M; Tsuchida, H; Katsuyama, K Novel dihydrothieno[2,3-e]indazole derivatives as I&x3ba;B kinase inhibitors. Bioorg Med Chem Lett21:1758-62 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Synonyms: | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IKK-A | IKK-alpha | IKK1 | IKK2/IKK1 | IKKA | IKKA_HUMAN | IkBKA | IkappaB kinase | Inhibitor of NF-kappa-B kinase alpha/beta | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16 |
Type: | PROTEIN |
Mol. Mass.: | 84642.21 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327453 |
Residue: | 745 |
Sequence: | MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
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BDBM50338236 |
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n/a |
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Name | BDBM50338236 |
Synonyms: | 7-(1-(4-chlorobenzyl)piperidin-3-yl)-2-ureido-5,7-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide | CHEMBL1681984 |
Type | Small organic molecule |
Emp. Form. | C23H25ClN6O2S |
Mol. Mass. | 485.002 |
SMILES | NC(=O)Nc1sc-2c(CCc3nn(cc-23)C2CCCN(Cc3ccc(Cl)cc3)C2)c1C(N)=O |
Structure |
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