Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
---|
Ligand | BDBM50338240 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_727955 (CHEMBL1686753) |
---|
IC50 | >100000±n/a nM |
---|
Citation | Takahashi, H; Shinoyama, M; Komine, T; Nagao, M; Suzuki, M; Tsuchida, H; Katsuyama, K Novel dihydrothieno[2,3-e]indazole derivatives as I&x3ba;B kinase inhibitors. Bioorg Med Chem Lett21:1758-62 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Inhibitor of nuclear factor kappa-B kinase subunit alpha |
---|
Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Synonyms: | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IKK-A | IKK-alpha | IKK1 | IKK2/IKK1 | IKKA | IKKA_HUMAN | IkBKA | IkappaB kinase | Inhibitor of NF-kappa-B kinase alpha/beta | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16 |
Type: | PROTEIN |
Mol. Mass.: | 84642.21 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327453 |
Residue: | 745 |
Sequence: | MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
|
|
|
BDBM50338240 |
---|
n/a |
---|
Name | BDBM50338240 |
Synonyms: | 7-(1-(2-fluoro-4-methoxybenzyl)piperidin-3-yl)-2-ureido-5,7-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide | CHEMBL1681990 |
Type | Small organic molecule |
Emp. Form. | C24H27FN6O3S |
Mol. Mass. | 498.573 |
SMILES | COc1ccc(CN2CCCC(C2)n2cc-3c(CCc4c-3sc(NC(N)=O)c4C(N)=O)n2)c(F)c1 |
Structure |
|