| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50341772 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743545 (CHEMBL1767986) |
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| EC50 | 219±n/a nM |
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| Citation |  Qian, Y; Wertheimer, SJ; Ahmad, M; Cheung, AW; Firooznia, F; Hamilton, MM; Hayden, S; Li, S; Marcopulos, N; McDermott, L; Tan, J; Yun, W; Guo, L; Pamidimukkala, A; Chen, Y; Huang, KS; Ramsey, GB; Whittard, T; Conde-Knape, K; Taub, R; Rondinone, CM; Tilley, J; Bolin, D Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem54:2433-46 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM50341772 |
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| n/a |
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| Name | BDBM50341772 |
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| Synonyms: | 5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-carboxylic AcidMethyl Ester | CHEMBL1766891 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21F3N4O4 |
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| Mol. Mass. | 474.4324 |
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| SMILES | COC(=O)N1CCC(CC1)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1 |
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| Structure | 
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