| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 12 |
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| Ligand | BDBM50342279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743865 (CHEMBL1767808) |
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| IC50 | 138±n/a nM |
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| Citation |  Wempe, MF; Jutabha, P; Quade, B; Iwen, TJ; Frick, MM; Ross, IR; Rice, PJ; Anzai, N; Endou, H Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem54:2701-13 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 12 |
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| Name: | Solute carrier family 22 member 12 |
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| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59638.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96S37 |
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| Residue: | 553 |
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| Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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| BDBM50342279 |
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| n/a |
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| Name | BDBM50342279 |
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| Synonyms: | (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-benzofuran-3-yl)methanone | CHEMBL1767079 | US9725430, Compound 1g | US9962362, Compound 1g |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Br2O4 |
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| Mol. Mass. | 440.083 |
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| SMILES | CCc1oc2cc(O)ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 |
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| Structure | 
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