Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50356336 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_775369 (CHEMBL1912854) | ||
IC50 | 4.9±n/a nM | ||
Citation | Ye, XY; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). Bioorg Med Chem Lett21:6699-704 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50356336 | |||
n/a | |||
Name | BDBM50356336 | ||
Synonyms: | CHEMBL1911413 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H23ClO2 | ||
Mol. Mass. | 318.838 | ||
SMILES | OC(=O)CC1(Cc2ccccc2Cl)C2CC3CC(C2)CC1C3 |TLB:21:20:18:14.15.16,3:4:14.21.15:19.17.18,THB:21:15:4.20.19:18,16:15:4:19.17.18,16:17:4:14.21.15,3:4:18:14.15.16,5:4:14.21.15:19.17.18,(-6.8,-7.84,;-5.47,-8.62,;-4.13,-7.85,;-5.47,-10.16,;-4.13,-10.94,;-4.87,-12.29,;-6.41,-12.32,;-7.2,-10.99,;-8.74,-11.02,;-9.48,-12.37,;-8.68,-13.69,;-7.15,-13.66,;-6.35,-14.97,;-2.93,-9.66,;-1.6,-10.15,;-.21,-9.8,;-.2,-8.27,;-1.59,-7.69,;-2.94,-8.17,;-2.63,-8.93,;-2.63,-10.52,;-1.22,-11.08,)| | ||
Structure |