| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase PKM |
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| Ligand | BDBM50361488 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_797232 (CHEMBL1942547) |
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| EC50 | 70±n/a nM |
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| Citation |  Walsh, MJ; Brimacombe, KR; Veith, H; Bougie, JM; Daniel, T; Leister, W; Cantley, LC; Israelsen, WJ; Vander Heiden, MG; Shen, M; Auld, DS; Thomas, CJ; Boxer, MB 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett21:6322-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase PKM |
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| Name: | Pyruvate kinase PKM |
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| Synonyms: | KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2) |
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| Type: | Protein |
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| Mol. Mass.: | 57944.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14618 |
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| Residue: | 531 |
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| Sequence: | MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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| BDBM50361488 |
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| n/a |
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| Name | BDBM50361488 |
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| Synonyms: | CHEMBL1939115 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17ClN2O3S |
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| Mol. Mass. | 364.846 |
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| SMILES | Cc1ccc(NS(=O)(=O)c2cc3NC(=O)CCc3cc2Cl)cc1C |
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| Structure | 
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