| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50362282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_798647 (CHEMBL1942636) |
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| IC50 | 14.3±n/a nM |
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| Citation |  Saito, T; Obitsu, T; Kohno, H; Sugimoto, I; Matsushita, T; Nishiyama, T; Hirota, T; Takeda, H; Matsumura, N; Ueno, S; Kishi, A; Kagamiishi, Y; Nakai, H; Takaoka, Y Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF¿?) receptor antagonists. Bioorg Med Chem20:1122-38 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 415 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV
HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF
PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50362282 |
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| n/a |
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| Name | BDBM50362282 |
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| Synonyms: | CHEMBL1939581 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22ClN3O2 |
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| Mol. Mass. | 359.85 |
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| SMILES | CCC(CC)c1cc(C)n2nc([nH]c(=O)c12)-c1ccc(OC)cc1Cl |
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| Structure | 
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