Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50365503 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_807676 (CHEMBL1959441) |
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IC50 | 740±n/a nM |
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Citation | Hirata, Y; Hirata, M; Kawaratani, Y; Shibano, M; Taniguchi, M; Yasuda, M; Ohmomo, Y; Nagaoka, Y; Baba, K; Uesato, S Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain. Bioorg Med Chem Lett22:1926-30 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50365503 |
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n/a |
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Name | BDBM50365503 |
Synonyms: | CHEMBL1957463 |
Type | Small organic molecule |
Emp. Form. | C28H27N3O4S |
Mol. Mass. | 501.597 |
SMILES | Nc1ccc(cc1NC(=O)c1ccc(CN(CCO)Cc2ccc3OCOc3c2)cc1)-c1cccs1 |
Structure |
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