| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50072242 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_220149 (CHEMBL881158) |
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| IC50 | 3300±n/a nM |
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| Citation |  Giordani, A; Pevarello, P; Cini, M; Bormetti, R; Greco, F; Toma, S; Speciale, C; Varasi, M 4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase. Bioorg Med Chem Lett8:2907-12 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO | KMO_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55831.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487479 |
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| Residue: | 486 |
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| Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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| BDBM50072242 |
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| n/a |
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| Name | BDBM50072242 |
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| Synonyms: | 4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric acid | CHEMBL99339 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8Cl2O4 |
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| Mol. Mass. | 263.074 |
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| SMILES | OC(CC(=O)c1ccc(Cl)c(Cl)c1)C(O)=O |
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| Structure | 
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