Reaction Details |
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Target | Neuromedin-K receptor |
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Ligand | BDBM50175494 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_209563 |
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Ki | 200±n/a nM |
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Citation | Bernstein, PR; Aharony, D; Albert, JS; Andisik, D; Barthlow, HG; Bialecki, R; Davenport, T; Dedinas, RF; Dembofsky, BT; Koether, G; Kosmider, BJ; Kirkland, K; Ohnmacht, CJ; Potts, W; Rumsey, WL; Shen, L; Shenvi, A; Sherwood, S; Stollman, D; Russell, K Discovery of novel, orally active dual NK1/NK2 antagonists. Bioorg Med Chem Lett11:2769-73 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neuromedin-K receptor |
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Name: | Neuromedin-K receptor |
Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
Type: | Enzyme |
Mol. Mass.: | 52221.96 |
Organism: | Homo sapiens (Human) |
Description: | P29371 |
Residue: | 465 |
Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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BDBM50175494 |
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n/a |
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Name | BDBM50175494 |
Synonyms: | 1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl}-4-phenyl-piperidine-4-carboxylic acid amide | 3-((E)-3-Carboxy-3-phenyl-allyl)-4,6-dichloro-1H-indole-2-carboxylic acid | CHEMBL330366 | MDL 104,335 (S)-enantiomer | MDL-105212 |
Type | Small organic molecule |
Emp. Form. | C34H39Cl2N3O5 |
Mol. Mass. | 640.597 |
SMILES | COc1cc(cc(OC)c1OC)C(=O)N1CC[C@@](CCN2CCC(CC2)(C(N)=O)c2ccccc2)(C1)c1ccc(Cl)c(Cl)c1 |
Structure |
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