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TargetEstrogen receptor beta
LigandBDBM50144780
Substrate/Competitorn/a
Meas. Tech.ChEMBL_67671 (CHEMBL673864)
EC50 16±n/a nM
Citation Yang, WWang, YMa, ZGolla, RStouch, TSeethala, RJohnson, SZhou, RGüngör, TFeyen, JHDickson, JK Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor beta agonists. Bioorg Med Chem Lett14:2327-30 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Estrogen receptor beta
Name:Estrogen receptor beta
Synonyms:ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:Protein
Mol. Mass.:59238.43
Organism:Homo sapiens (Human)
Description:Q92731
Residue:530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50144780
n/a
NameBDBM50144780
Synonyms:3-(3-Bromo-4-hydroxy-phenyl)-2,5-dimethyl-2H-benzo[1,4]oxazin-7-ol | CHEMBL77620
TypeSmall organic molecule
Emp. Form.C16H14BrNO3
Mol. Mass.348.191
SMILESCC1Oc2cc(O)cc(C)c2N=C1c1ccc(O)c(Br)c1 |c:12|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: