Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50085284 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_220427 (CHEMBL841667) |
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IC50 | 1650±n/a nM |
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Citation | Penning, TD; Chandrakumar, NS; Chen, BB; Chen, HY; Desai, BN; Djuric, SW; Docter, SH; Gasiecki, AF; Haack, RA; Miyashiro, JM; Russell, MA; Yu, SS; Corley, DG; Durley, RC; Kilpatrick, BF; Parnas, BL; Askonas, LJ; Gierse, JK; Harding, EI; Highkin, MK; Kachur, JF; Kim, SH; Krivi, GG; Villani-Price, D; Pyla, EY; Smith, WG Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem43:721-35 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50085284 |
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n/a |
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Name | BDBM50085284 |
Synonyms: | 1-[2-(4-Benzyl-phenoxy)-ethyl]-4-methyl-piperazine | CHEMBL163428 |
Type | Small organic molecule |
Emp. Form. | C20H26N2O |
Mol. Mass. | 310.4332 |
SMILES | CN1CCN(CCOc2ccc(Cc3ccccc3)cc2)CC1 |
Structure |
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