Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Thyroid hormone receptor alpha |
---|
Ligand | BDBM50151074 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_302715 (CHEMBL839586) |
---|
Ki | 790±n/a nM |
---|
Citation | von Geldern, TW; Tu, N; Kym, PR; Link, JT; Jae, HS; Lai, C; Apelqvist, T; Rhonnstad, P; Hagberg, L; Koehler, K; Grynfarb, M; Goos-Nilsson, A; Sandberg, J; Osterlund, M; Barkhem, T; Höglund, M; Wang, J; Fung, S; Wilcox, D; Nguyen, P; Jakob, C; Hutchins, C; Färnegårdh, M; Kauppi, B; Ohman, L; Jacobson, PB Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes. J Med Chem47:4213-30 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thyroid hormone receptor alpha |
---|
Name: | Thyroid hormone receptor alpha |
Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 |
Type: | Receptor |
Mol. Mass.: | 54818.00 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. |
Residue: | 490 |
Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
|
|
|
BDBM50151074 |
---|
n/a |
---|
Name | BDBM50151074 |
Synonyms: | CHEMBL364368 | N-[4-((2R,8S,13S,14S,17R)-17-Ethynyl-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-2-yl)-phenyl]-N-methyl-acetamide |
Type | Small organic molecule |
Emp. Form. | C29H33NO3 |
Mol. Mass. | 443.5772 |
SMILES | CN(C(C)=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:27,34| |
Structure |
|