Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50189733 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_367960 (CHEMBL871108) |
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IC50 | 0.06±n/a nM |
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Citation | Imada, T; Cho, N; Imaeda, T; Hayase, Y; Sasaki, S; Kasai, S; Harada, M; Matsumoto, H; Endo, S; Suzuki, N; Furuya, S Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem49:3809-25 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50189733 |
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n/a |
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Name | BDBM50189733 |
Synonyms: | CHEMBL379629 | ethyl 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-[4-(3-methyluriedo)phenyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate |
Type | Small organic molecule |
Emp. Form. | C34H32F2N4O4S |
Mol. Mass. | 630.704 |
SMILES | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(c(CN(C)Cc3ccccc3)c2c1=O)-c1ccc(NC(=O)NC)cc1 |
Structure |
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