| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50190526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_373787 (CHEMBL869751) |
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| IC50 | >30000±n/a nM |
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| Citation |  Habashita, H; Kokubo, M; Hamano, S; Hamanaka, N; Toda, M; Shibayama, S; Tada, H; Sagawa, K; Fukushima, D; Maeda, K; Mitsuya, H Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists. J Med Chem49:4140-52 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50190526 |
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| n/a |
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| Name | BDBM50190526 |
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| Synonyms: | (3S)-1,9-dibenzyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride | CHEMBL539854 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33N3O2 |
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| Mol. Mass. | 419.5591 |
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| SMILES | CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O |
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| Structure | 
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