Reaction Details |
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Target | Tissue-type plasminogen activator |
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Ligand | BDBM50228413 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_452507 (CHEMBL902746) |
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IC50 | 4000±n/a nM |
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Citation | Joossens, J; Ali, OM; El-Sayed, I; Surpateanu, G; Van der Veken, P; Lambeir, AM; Setyono-Han, B; Foekens, JA; Schneider, A; Schmalix, W; Haemers, A; Augustyns, K Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem50:6638-46 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tissue-type plasminogen activator |
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Name: | Tissue-type plasminogen activator |
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
Type: | Enzyme |
Mol. Mass.: | 62931.08 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 562 |
Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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BDBM50228413 |
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n/a |
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Name | BDBM50228413 |
Synonyms: | CHEMBL238708 | [1-Benzyloxycarbonylamino-2-(4-carbamimidoyl-phenyl)-ethyl]-phosphonic acid diphenyl ester | diphenyl 1-(N-benzyloxycarbonylamino)-2-(4-amidinophenyl)ethanephosphonate |
Type | Small organic molecule |
Emp. Form. | C29H28N3O5P |
Mol. Mass. | 529.5235 |
SMILES | NC(=N)c1ccc(CC(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 |
Structure |
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