Reaction Details |
| Report a problem with these data |
Target | NPC1-like intracellular cholesterol transporter 1 |
---|
Ligand | BDBM50371547 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_463744 (CHEMBL932102) |
---|
Ki | >50000±n/a nM |
---|
Citation | Pfefferkorn, JA; Larsen, SD; Van Huis, C; Sorenson, R; Barton, T; Winters, T; Auerbach, B; Wu, C; Wolfram, TJ; Cai, H; Welch, K; Esmaiel, N; Davis, J; Bousley, R; Olsen, K; Mueller, SB; Mertz, T Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption. Bioorg Med Chem Lett18:546-53 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NPC1-like intracellular cholesterol transporter 1 |
---|
Name: | NPC1-like intracellular cholesterol transporter 1 |
Synonyms: | NPCL1_RAT | Niemann-Pick C1-like protein 1 | Npc1l1 |
Type: | PROTEIN |
Mol. Mass.: | 146415.18 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_463744 |
Residue: | 1331 |
Sequence: | MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNT
PARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNF
VSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAA
ASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKI
APCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSA
VLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSF
IVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSY
KYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNT
SLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLAL
SCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEM
ESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRV
AVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLE
YQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAI
ILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFL
LHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPV
YFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDW
LTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDP
PNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITAD
LRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGI
LNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLE
RAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLP
VVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAA
RSSLPKSDQKF
|
|
|
BDBM50371547 |
---|
n/a |
---|
Name | BDBM50371547 |
Synonyms: | CHEMBL436647 |
Type | Small organic molecule |
Emp. Form. | C26H27NO4 |
Mol. Mass. | 417.4969 |
SMILES | COc1ccc(cc1)[C@@H]1[C@@H](CCCc2ccccc2)OC(=O)N1c1ccc(OC)cc1 |
Structure |
|