| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50377588 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479735 (CHEMBL929232) |
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| IC50 | 0.5±n/a nM |
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| Citation |  Azim, MK; Ahmed, W; Khan, IA; Rao, NA; Khan, KM Identification of acridinyl hydrazides as potent aspartic protease inhibitors. Bioorg Med Chem Lett18:3011-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50377588 |
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| n/a |
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| Name | BDBM50377588 |
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| Synonyms: | CHEMBL257594 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N3O2 |
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| Mol. Mass. | 357.4052 |
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| SMILES | Cc1ccc2c(NNC(=O)c3ccccc3O)c3ccccc3nc2c1C |
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| Structure | 
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