| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
|---|
| Ligand | BDBM50262446 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_513983 (CHEMBL975428) |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Zhang, S; Ma, J; Bao, Y; Yang, P; Zou, L; Li, K; Sun, X Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity. Bioorg Med Chem16:7128-33 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 1 |
|---|
| Name: | Cyclin-dependent kinase 1 |
|---|
| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 34101.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06493 |
|---|
| Residue: | 297 |
|---|
| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
|
|
|
|---|
| BDBM50262446 |
|---|
| n/a |
|---|
| Name | BDBM50262446 |
|---|
| Synonyms: | (E)-1-(5-((dimethylamino)methyl)-2-hydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one | CHEMBL450358 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21NO3 |
|---|
| Mol. Mass. | 311.3749 |
|---|
| SMILES | COc1cc(O)c(cc1CN(C)C)C(=O)\C=C\c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
