Reaction Details |
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Target | Glutamate receptor 4 |
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Ligand | BDBM50060635 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_539474 (CHEMBL1028970) |
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Ki | 123±n/a nM |
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Citation | Butini, S; Pickering, DS; Morelli, E; Coccone, SS; Trotta, F; De Angelis, M; Guarino, E; Fiorini, I; Campiani, G; Novellino, E; Schousboe, A; Christensen, JK; Gemma, S 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. J Med Chem51:6614-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutamate receptor 4 |
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Name: | Glutamate receptor 4 |
Synonyms: | GRIA4_RAT | Glur4 | Glutamate receptor ionotropic, AMPA 4 | Glutamate receptors NMDA/AMPA | Gria4 |
Type: | PROTEIN |
Mol. Mass.: | 100766.57 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_539474 |
Residue: | 902 |
Sequence: | MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEA
PFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITP
SFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH
VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIA
NLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSAL
TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN
VQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVT
TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK
IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL
DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW
FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED
LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG
KFAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGL
LDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS
RAEAKRMKLTFSEATRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASD
LP
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BDBM50060635 |
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n/a |
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Name | BDBM50060635 |
Synonyms: | (S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid | (S)-2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid | (S)-5-Fluorowillardiine | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID | CHEMBL123132 | Fluorowillardiine |
Type | Small organic molecule |
Emp. Form. | C7H8FN3O4 |
Mol. Mass. | 217.1545 |
SMILES | N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(O)=O |r| |
Structure |
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