| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 3 |
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| Ligand | BDBM50326053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_586828 (CHEMBL1063805) |
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| Kd | 220±n/a nM |
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| Citation |  Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol26:127-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 3 |
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| Name: | Serine/threonine-protein kinase 3 |
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| Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 56284.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 491 |
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| Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
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| BDBM50326053 |
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| n/a |
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| Name | BDBM50326053 |
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| Synonyms: | CHEMBL608533 | PKC-412 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H30N4O4 |
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| Mol. Mass. | 570.6371 |
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| SMILES | CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |r| |
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| Structure | 
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