| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Mdm4 |
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| Ligand | BDBM50382114 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_815413 (CHEMBL2027065) |
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| IC50 | 70000±n/a nM |
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| Citation |  Furet, P; Chène, P; De Pover, A; Valat, TS; Lisztwan, JH; Kallen, J; Masuya, K The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett22:3498-502 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Mdm4 |
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| Name: | Protein Mdm4 |
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| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 54842.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
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| Residue: | 490 |
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| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
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| BDBM50382114 |
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| n/a |
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| Name | BDBM50382114 |
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| Synonyms: | CHEMBL2024320 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26ClN3O |
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| Mol. Mass. | 431.957 |
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| SMILES | COc1ccc(Cn2c(C)nc(Cc3ccc(N)cc3)c2Cc2ccc(Cl)cc2)cc1 |
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| Structure | 
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