| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Smoothened homolog |
|---|
| Ligand | BDBM50392957 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_853480 (CHEMBL2155377) |
|---|
| IC50 | 5000±n/a nM |
|---|
| Citation |  Dockendorff, C; Nagiec, MM; Weïwer, M; Buhrlage, S; Ting, A; Nag, PP; Germain, A; Kim, HJ; Youngsaye, W; Scherer, C; Bennion, M; Xue, L; Stanton, BZ; Lewis, TA; Macpherson, L; Palmer, M; Foley, MA; Perez, JR; Schreiber, SL Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. ACS Med Chem Lett3:808-813 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Smoothened homolog |
|---|
| Name: | Smoothened homolog |
|---|
| Synonyms: | SMO_MOUSE | Smo | Smoh |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 87472.73 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1510377 |
|---|
| Residue: | 793 |
|---|
| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
|
|
|
|---|
| BDBM50392957 |
|---|
| n/a |
|---|
| Name | BDBM50392957 |
|---|
| Synonyms: | CHEMBL2152357 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27ClN2O4 |
|---|
| Mol. Mass. | 454.946 |
|---|
| SMILES | Clc1ccc(CNC(=O)C[C@@H]2C\C=C\CCC(=O)N[C@@H](COC2=O)c2ccccc2)cc1 |r,t:12| |
|---|
| Structure | 
|
|---|
Search and Browse
