| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptides B/W receptor type 1 |
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| Ligand | BDBM75896 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_887068 (CHEMBL2213859) |
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| IC50 | 580±n/a nM |
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| Citation |  Urbano, M; Guerrero, M; Zhao, J; Velaparthi, S; Saldanha, SA; Chase, P; Wang, Z; Civelli, O; Hodder, P; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Bioorg Med Chem Lett22:7135-41 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptides B/W receptor type 1 |
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| Name: | Neuropeptides B/W receptor type 1 |
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| Synonyms: | GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36111.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119607128 |
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| Residue: | 328 |
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| Sequence: | MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLY
VLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNT
FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD
DEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK
ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS
CLNPFLYAFLDASFRRNLRQLITCRAAA
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| BDBM75896 |
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| n/a |
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| Name | BDBM75896 |
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| Synonyms: | 5-chloranyl-2-(4-ethylphenyl)-4-(4-methoxyphenoxy)pyridazin-3-one | 5-chloro-2-(4-ethylphenyl)-4-(4-methoxyphenoxy)-3-pyridazinone | 5-chloro-2-(4-ethylphenyl)-4-(4-methoxyphenoxy)pyridazin-3-one | SR-02000000367 | SR-02000000367-1 | cid_46172935 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17ClN2O3 |
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| Mol. Mass. | 356.803 |
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| SMILES | CCc1ccc(cc1)-n1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O |
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| Structure | 
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