| Reaction Details |
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 | Report a problem with these data |
| Target | Progesterone receptor |
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| Ligand | BDBM50417607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_698230 (CHEMBL1646700) |
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| EC50 | 794.33±n/a nM |
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| Citation |  Brown, AR; Bosies, M; Cameron, H; Clark, J; Cowley, A; Craighead, M; Elmore, MA; Firth, A; Goodwin, R; Goutcher, S; Grant, E; Grassie, M; Grove, SJ; Hamilton, NM; Hampson, H; Hillier, A; Ho, KK; Kiczun, M; Kingsbury, C; Kultgen, SG; Littlewood, PT; Lusher, SJ; Macdonald, S; McIntosh, L; McIntyre, T; Mistry, A; Morphy, JR; Nimz, O; Ohlmeyer, M; Pick, J; Rankovic, Z; Sherborne, B; Smith, A; Speake, M; Spinks, G; Thomson, F; Watson, L; Weston, M Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist. Bioorg Med Chem Lett21:137-40 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Progesterone receptor |
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| Name: | Progesterone receptor |
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| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
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| Type: | Protein |
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| Mol. Mass.: | 98979.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06401 |
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| Residue: | 933 |
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| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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| BDBM50417607 |
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| n/a |
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| Name | BDBM50417607 |
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| Synonyms: | CHEMBL1645401 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F4N3O3S |
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| Mol. Mass. | 457.442 |
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| SMILES | COc1ccc(F)cc1-c1ccc(cc1)[C@@H](C)NS(=O)(=O)c1cn(C)nc1C(F)(F)F |r| |
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| Structure | 
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