Reaction Details |
| Report a problem with these data |
Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
---|
Ligand | BDBM50348352 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_757614 (CHEMBL1804871) |
---|
IC50 | 4600±n/a nM |
---|
Citation | Gage, JL; Onrust, R; Johnston, D; Osnowski, A; Macdonald, W; Mitchell, L; Urögdi, L; Rohde, A; Harbol, K; Gragerov, S; Dormán, G; Wheeler, T; Florio, V; Cutshall, NS N-Acylhydrazones as inhibitors of PDE10A. Bioorg Med Chem Lett21:4155-9 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
---|
Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
Synonyms: | PDE10_MOUSE | Pde10a |
Type: | PROTEIN |
Mol. Mass.: | 89407.64 |
Organism: | Mus musculus |
Description: | ChEMBL_1458264 |
Residue: | 790 |
Sequence: | MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKD
EPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYF
LGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRG
TGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ
VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN
KELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV
DLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMW
PGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNG
LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVI
GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKST
PEKLNVKVED
|
|
|
BDBM50348352 |
---|
n/a |
---|
Name | BDBM50348352 |
Synonyms: | CHEMBL1800305 |
Type | Small organic molecule |
Emp. Form. | C21H20ClN3O3S |
Mol. Mass. | 429.92 |
SMILES | COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)c(Cl)c1OC |
Structure |
|