| Reaction Details |
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 | Report a problem with these data |
| Target | Microsomal triglyceride transfer protein large subunit |
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| Ligand | BDBM50437016 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_971724 (CHEMBL2404393) |
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| IC50 | 25±n/a nM |
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| Citation |  Chai, W; Wong, VD; Nepomuceno, D; Bonaventure, P; Lovenberg, TW; Carruthers, NI The discovery of potent selective NPY Y(2) antagonists. Bioorg Med Chem Lett23:4141-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Microsomal triglyceride transfer protein large subunit |
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| Name: | Microsomal triglyceride transfer protein large subunit |
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| Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99365.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_971724 |
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| Residue: | 894 |
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| Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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| BDBM50437016 |
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| n/a |
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| Name | BDBM50437016 |
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| Synonyms: | CHEMBL2402907 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32FN3O2S |
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| Mol. Mass. | 541.679 |
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| SMILES | CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccsc2)cc1F)c1ccccc1 |
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| Structure | 
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