| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50437698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_974557 (CHEMBL2410145) |
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| IC50 | 1150±n/a nM |
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| Citation |  Han, ML; Shen, Y; Wang, GC; Leng, Y; Zhang, H; Yue, JM 11ß-HSD1 inhibitors from Walsura cochinchinensis. J Nat Prod76:1319-27 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32369.70 |
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| Organism: | Mus musculus (mouse) |
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| Description: | P50172 |
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| Residue: | 292 |
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| Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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| BDBM50437698 |
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| n/a |
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| Name | BDBM50437698 |
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| Synonyms: | CHEMBL2409066 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H48O4 |
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| Mol. Mass. | 472.6997 |
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| SMILES | CC(C)CC(=O)C(=O)[C@H](C)[C@@H]1CC[C@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@@H](O)[C@@]12C |r,t:15| |
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| Structure | 
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