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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent glycine transporter 1 | ||
| Ligand | BDBM50439740 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_980599 (CHEMBL2423116) | ||
| IC50 | 250±n/a nM | ||
| Citation |  Sugane, T; Tobe, T; Hamaguchi, W; Shimada, I; Maeno, K; Miyata, J; Suzuki, T; Kimizuka, T; Sakamoto, S; Tsukamoto, S Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors. J Med Chem56:5744-56 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent glycine transporter 1 | |||
| Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
| Synonyms: | GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 71066.17 | ||
| Organism: | attus norvegicus (Rat) | ||
| Description: | Glycine-1-transporter 0 HUMAN::P28572 | ||
| Residue: | 638 | ||
| Sequence: |
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| BDBM50439740 | |||
| n/a | |||
| Name | BDBM50439740 | ||
| Synonyms: | CHEMBL2419428 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N3O | ||
| Mol. Mass. | 369.4589 | ||
| SMILES | CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(CO)c1C |(14.92,-39.34,;13.65,-40.21,;12.26,-39.55,;11.78,-38.08,;10.24,-38.09,;9.77,-39.55,;8.44,-40.31,;7.11,-39.53,;5.78,-40.29,;5.76,-41.83,;7.1,-42.61,;8.44,-41.85,;4.43,-42.59,;3.1,-41.81,;1.76,-42.57,;1.75,-44.11,;3.09,-44.89,;4.42,-44.13,;11.02,-40.45,;11.03,-41.99,;9.7,-42.76,;9.69,-44.31,;11.03,-45.08,;12.37,-44.31,;13.7,-45.08,;13.7,-46.62,;12.36,-42.76,;13.69,-41.98,)| | ||
| Structure | 
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