| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
|---|
| Ligand | BDBM50443760 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1279907 (CHEMBL3096167) |
|---|
| IC50 | 470±n/a nM |
|---|
| Citation |  Wang, J; Feng, Y; Ji, X; Deng, G; Leng, Y; Liu, H Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem21:7418-29 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl endopeptidase FAP |
|---|
| Name: | Prolyl endopeptidase FAP |
|---|
| Synonyms: | 170 kDa melanoma membrane-bound gelatinase | FAP | Fibroblast Activation Protein (FAP) | Fibroblast activation protein alpha | Integral membrane serine protease | SEPR_HUMAN | Seprase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 87712.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q12884 |
|---|
| Residue: | 760 |
|---|
| Sequence: | MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPN
WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYG
DEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVT
DERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYD
AISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPG
RRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGR
TDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQ
ITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVY
TERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD
|
|
|
|---|
| BDBM50443760 |
|---|
| n/a |
|---|
| Name | BDBM50443760 |
|---|
| Synonyms: | CHEMBL3093904 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18FN3O |
|---|
| Mol. Mass. | 275.3213 |
|---|
| SMILES | Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
