Reaction Details |
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Target | C-C chemokine receptor type 1 |
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Ligand | BDBM50056503 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1452285 (CHEMBL3366539) |
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IC50 | 6.0±n/a nM |
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Citation | Santella, JB; Gardner, DS; Duncia, JV; Wu, H; Dhar, M; Cavallaro, C; Tebben, AJ; Carter, PH; Barrish, JC; Yarde, M; Briceno, SW; Cvijic, ME; Grafstrom, RR; Liu, R; Patel, SR; Watson, AJ; Yang, G; Rose, AV; Vickery, RD; Caceres-Cortes, J; Caporuscio, C; Camac, DM; Khan, JA; An, Y; Foster, WR; Davies, P; Hynes, J Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem57:7550-64 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 1 |
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Name: | C-C chemokine receptor type 1 |
Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
Type: | Enzyme |
Mol. Mass.: | 41180.69 |
Organism: | Homo sapiens (Human) |
Description: | P32246 |
Residue: | 355 |
Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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BDBM50056503 |
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n/a |
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Name | BDBM50056503 |
Synonyms: | CHEMBL3334823 |
Type | Small organic molecule |
Emp. Form. | C22H34ClN3O4 |
Mol. Mass. | 439.976 |
SMILES | C[C@@H](O)CNC(=O)N[C@H](C(C)C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 |r| |
Structure |
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