| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled bile acid receptor 1 |
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| Ligand | BDBM50081118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475559 (CHEMBL3424620) |
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| EC50 | 5000±n/a nM |
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| Citation |  Duan, H; Ning, M; Zou, Q; Ye, Y; Feng, Y; Zhang, L; Leng, Y; Shen, J Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes. J Med Chem58:3315-28 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled bile acid receptor 1 |
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| Name: | G-protein coupled bile acid receptor 1 |
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| Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 35260.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHO cells transiently transfected with hTGR5. |
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| Residue: | 330 |
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| Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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| BDBM50081118 |
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| n/a |
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| Name | BDBM50081118 |
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| Synonyms: | CHEMBL3421898 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32Cl2N4O5 |
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| Mol. Mass. | 611.516 |
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| SMILES | CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc23)cc1Cl |
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| Structure | 
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