Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM254160 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1616384 (CHEMBL3858453) |
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Ki | 7.0±n/a nM |
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Citation | Swanson, DM; Savall, BM; Coe, KJ; Schoetens, F; Koudriakova, T; Skaptason, J; Wall, J; Rech, J; Deng, X; De Angelis, M; Everson, A; Lord, B; Wang, Q; Ao, H; Scott, B; Sepassi, K; Lovenberg, TW; Carruthers, NI; Bhattacharya, A; Letavic, MA Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. J Med Chem59:8535-48 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68403.50 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q64663 |
Residue: | 595 |
Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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BDBM254160 |
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n/a |
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Name | BDBM254160 |
Synonyms: | US10112937, Example 40 | US10150765, Example 40 | US10703749, Example 11 | US9464084, 40 |
Type | Small organic molecule |
Emp. Form. | C20H15ClF4N4O |
Mol. Mass. | 438.806 |
SMILES | C[C@H]1N(CCc2c1ncn2-c1ccc(F)cn1)C(=O)c1cccc(c1Cl)C(F)(F)F |r| |
Structure |
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